Everything running smoothly now. Operation Anchorage wasn't great, but The Pitt was excellent, and Point Lookout is fucking fantastic so far. Then again, I have a clearly-documented history of favoritism towards surreal dream sequences in video games, so [spoiler]the visions you experience while high on the spores of the giant Punga plant and also being trepanned[/spoiler] were A++ for me.
Haven't gotten to the Broken Steel content yet, but I'm high enough level that some of the monsters have started showing up, and by god but those things can put the fear of God into me. I don't know how much health those fucking Super Mutant Overlords have, but if I had to guess, I'd put the number at somewhere around a zillion. The biggest issue here is that if new enemies spawn as part of a scripted encounter, they can dramatically throw off the expected balance of power - the entirety of my BoS Outcast entourage en route to their base for Operation Anchorage was slaughtered by a single Overlord with a gatling laser.
tl;dr I think I'm going to start carrying a rocket launcher with me at all times.