You wouldn't think a game as heavy on player choice as Mass Effect would lend itself very well to a comic...and you'd be right!
First off: Shepard is never referred to by a pronoun. Sound awkward? It is!
While the comic manages to avoid defining a gender for Shepard, it DOES eventually have to narrow itself down on which ending it follows. It's not the one where the entire Council is replaced by humans. Other than that, it's still open.
Anyway, very meh. I think it would have been better if it were a prequel, or something only very tangentially related to Shepard's story. Expand the universe a bit without worrying about having to accomodate player choice. Because there isn't any, because it's a fucking comic book.
(Although it occurs to me that there is actually untapped webcomic potential here: it would be fairly trivial for BioWare to rig up an online version of the comic that loads a save and very slightly alters dialogue based on it. That would actually be pretty fucking cool IMO!)