...can't get ME2 to work reliably anymore; bluescreens most times I run it. I blame running a non-Apple graphics card in a Mac Pro (though Witcher 2 didn't do it nearly as often and presumably was working the card harder).
Same problem when I run it under WINE. Except also the music doesn't work.
(EDIT: Music works if I bypass the launcher and just run masseffect2.exe. But it still crashes. I guess on the plus side it seems to mostly wait to crash after I load my save, while Windows often crashes as soon as I Press Any Key at the start screen. So maybe if I go back far enough on my saves I'll find something that doesn't crash.)
Still fightin'. Crashes like crazy in Windows at this point. Linux I actually had it sort of working in WINE but not quite.
The WINE version in the standard Ubu repos: runs, but mouselook isn't 360-degree; something to do with how X reads mouse movement. I think it must stop at the edge of the window. Additionally, I can't mouselook while running, which as you might expect is a problem.
From the WINE repos:
1.2 runs, but the picture disappears once I load my save. Audio works, so it doesn't seem to have locked up; it just doesn't display.
1.3 runs but the keyboard and mouse don't work on the main menu screen. Mouse pointer moves but doesn't highlight menu items; neither clicking nor keypresses work (though they work on the Press Any Key screen, and Alt-F4 still quits out even at the menu screen).
Looking into these various problems. May end up having to roll my own.
(Also tried again to get my non-Apple graphics card working under OSX. Still haven't had any luck but haven't given up just yet. If I continue to have issues, I may install the Chameleon bootloader -- among hypothetical support for my graphics card, it'll let me use the 64-bit kernel and run Mountain Lion should I decide I actually want to do that.)