This is something I really appreciated about ME. It took a lot of care to write out Shepard's dialogue, then have it recorded without having the player hate himself. I went Paragon and was dreading sounding like some hippie pussy because of it, but I didn't. There's something satisfyingly immersive about your character having a real voice when you choose the dialogue. That's something I liked about Deus Ex, too.
Jennifer Hale does fantastic work and totally overshadows her male counterpart. (Who sounds hilariously inappropriate if you play a Samuel L Jackson lookalike.)
Haven't played Dragon Age yet. I hear that certain party members will constantly bitch at you for your choices, and I'm not looking forward to that.
Yeah. It's probably not as bad as Freya in KotOR bitching every time you did anything positive OR negative, but on the other hand, Freya was one character and in this game anything you do is likely to piss SOMEBODY off. (Except your dog. And I haven't noticed Shale getting too pissed about much of anything, but I haven't had him for very long.)
It gets some points for not having an overt dark/light/paragon/renegade/good/evil/lawful/chaotic alignment system, but loses most of them for most of your choices being so black-and-white anyway. (There are exceptions! There's at least one major quest where an innocent person has to die, and you have to choose which one.) And your party members aren't strictly good/evil; it's more like one's religious, one's self-centered, one hates mages, and so on. Their motivations, while still comparatively simple, are more complex than you usually get in a game like this.
You know what was pretty good at the whole what-path-will-you-choose thing? The Witcher. Sure, some of the choices were hilariously black-and-white (don't help the fanatics burn the witch, don't kill the werewolf because he's actually a good guy, ...), but the major ones are pretty gray. To take the biggest example, you can choose to help out the soldiers or the nonhuman terrorists, but both factions are pretty fucked-up -- and you've got a choice to tell them all to go to hell, but in the end you have to suffer the consequences of refusing to take a side, too.
I smell a similar kind of moral quandary coming in Dragon Age, but haven't gotten to the obligatory BioWare Big Twist Moment yet.