1)Learn alchemy.
2)Mix DOOMSDAY POISON and UBER BATTLE TONICS
3)Throw all that lame, useless shit away. It blows. (Excepting some paralysis poisons. Those can be amazing)
4)Never look back.
I also carried several hundred pounds of potions and ingredients. At least 5 pounds of that are dedicated to potions that produce 100-450 points of feather for over 5 minutes.
The rest are potions that simultaneously bestow boosted strength, HP regeneration, and a boost to either intelligence, agility, or speed. Some magic tonics that simultaneously boost and regenerate magicka at some mad rate, or make intelligence jump by 30 points.
And let's not get me started on poisons. Do you know how cheap (i.e. hilarious) it is to add a weakness to poison enchantment on a weapon? Or better still blast some poor fucker with it and then watch as they simultaneously explode into flames, electricity, and straight wound damage (for a total between 60 and 90 points), AND collapse from paralysis for 2-3 seconds (all without any poison weakness)?
It's almost as game breaking as max chameleon.