I just got it. Well, okay, I got it a while ago and have just now started playing. Really enjoying it, though.
I'm surprised by the general lack of sleaze, though. Well, in relation to previous games in the series where you could be a porn star and sell your lesbian wife into sexual slavery. So far in the game the only thing my character has had sex with has been Fisto the sexbot.
Not that... uh... I play the Fallout games for the sleaze or anything.
ANYWAY: I'm disappointed in the general lack of diplomatic character builds. I like playing characters who rely almost entirely on charisma and smooth talking to get out of hairy situations in these sorts of RPGs (or when that fails, the lovely bruisers who accompany my character). Admittedly, I usually don't get very far in these RPGs because eventually you're expected to put up or shut up, and my under-leveled talker is usually not up to snuff.
Still, though, it looks as if there are only three perks that actually affect your dialog options, and one of them immediately throws you into combat. That's just lame.