Saga reminds me, cursorily, of New Gods. Because it's a space opera about a war between two planets that features obvious biblical symbolism, and because there is some fucking crazy shit going on.
That's really where the similarity ends. This isn't a superhero book, and it's not like Kirby in writing, pacing, or art. (Maybe in the themes and Big Ideas.) And yes it goes without saying that only Jack Kirby was Jack Kirby.
But so far I quite like it. I think, in the span of 32 pages(? they're not numbered and I didn't count, but it FELT like 32 pages -- for only $2.99!), Vaughan and Staples managed to create a neat, weird universe, and fill my head with questions that I legitimately hope go unanswered.
(Vaughan's good at that. It's easy to give readers an explanation for the Big Mysteries -- and just as easy to let them down with an anticlimax that is not anywhere near as interesting as the mystery itself was. What killed all the men in Y? YOU NEVER FIND OUT. And that may seem, to the untrained eye, like it's lazy or a copout -- but it's just the opposite. It's very good instinct and remarkable self-control on Vaughan's part.)
Really good start, and I can see why it seems to be the New Hotness and is purportedly selling out everywhere. If you can still find a copy at cover price, I definitely recommend getting it; if not, I suspect there'll be a second printing, the way things are going.